Serenity Test FAQs

FAQs: Serenity Prenatal Test
Frequently Asked Questions

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1.) Who will carry out the Serenity Prenatal Test?

Your appointment will be performed by one of our fully qualified healthcare professionals.
You will receive your results in a report sent to your email.

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2.) How accurate is the Serenity Prenatal Test?

Serenity’s DNA-based technology correctly identifies Down syndrome (Trisomy 21) in more than 99% of foetuses, 98% of foetuses with Edwards syndrome (Trisomy 18) and 98% of foetuses Patau’s syndrome (Trisomy 13).

Serenity has a very low false-positive result of 0.2% which is much lower than conventional screening which can have false positive rates of up to 5%, meaning there is much less chance your doctor would recommend follow-up invasive testing, such as amniocentesis or CVS.

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3.) Who should have the Serenity NIPT?

We offer the Serenity test to all pregnant women, anybody who would like extra reassurance about their pregnancy is welcome to come to one of our clinics for a test. The test is not aimed at over 35’s, although the risk of Down’s syndrome does increase with maternal age most cases of Down’s syndrome occur in women under 35.
The Serenity test can be carried out on pregnant women of all ages both under and over the 35 year age group.
Those who are anxious about having a baby with a chromosomal abnormality such as Down’s syndrome, Edwards syndrome or Patau’s syndrome, or who have previously had pregnancies with chromosomal abnormalities often opt for the test. Also any pregnancies who are at risk of miscarriage should they have CVS or amniocentesis also tend to opt for this option as there is a lower false positive rate which mean less chance of needing an invasive procedure.

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4.) When should I have the Serenity NIPT?

You can have the test as early as 10 weeks of pregnancy, or at any point after this.

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5.) What is involved in the Serenity Prenatal Test?

You will initially have an ultrasound performed by one of our qualified sonographers or midwife sonographers, this is to confirm that the gestational age is 10 weeks or over, and also to confirm that there is an on-going pregnancy and to check for multiple babies.
You will then be asked to return for a blood test where 2 tubes of blood will be taken from your arm, which will then be sent for lab testing.

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6.) How is Serenity different to other blood tests for Down’s Syndrome?

The Serenity test is able to deliver a much higher accuracy than conventional NHS tests giving you greater peace of mind. It is non-invasive, posing minimal risk to mother or baby, can test for more than just Down’s syndrome and can be carried out as early as 10 weeks’ pregnant.

Also the false positive of Serenity is much lower at 0.2% compared to conventional tests which can have a false positive rate of up to 5%, therefore there is a much higher chance of being asked to carry out further invasive tests such as CVS and amniocentesis with conventional testing.

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7.) What anomalies does the Serenity Prenatal Test check for?

Serenity is aimed at picking up trisomy’s 21,18 & 13. The detection rate for Down’s syndrome is greater than 99%, 98% for Edwards syndrome (Trisomy 18) and 98% for Patau’s syndrome (Trisomy 13).
There is also the option to have the sex chromosomes evaluated, this option tests for conditions caused by having a missing or an extra copy of X or Y chromosomes including Turners and Klinefelter syndromes*.

The Serenity test also has the option (Package 2) of testing for microdeletions, a microdeletion is where a small section of the genetic information on the chromosome is lost during the process of DNA replication. The size and position of the deletion will determine which clinical features are manifested and also the severity of the feature. The serenity test will quantify the risk of the foetus having 22q11 deletion (DiGeorge region),15q11 deletion (Angelman/ Prader-Wili) 1p36 deletion, 4p (Wolf-Hirschorn) 5p (Cri-du Chat)
*This option is only available in singleton pregnancies.

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8.)Does the Serenity NIPT pick up all anomalies?

No, the Serenity test does not test for all health problems, a normal result does not eliminate the possibility that your pregnancy may have other chromosomal/genetic defects, birth defects or other complications. A “No aneuploidy Detected” result in this test does not completely rule out the presence of the conditions being tested for, and does not guarantee the health of your baby.
The Sernity test is designed to look at full chromosomes aneuploidies only and has been validated for chromosomes 13,18, 21 & sex chromosomes only. There is a small possibility that the test results may not reflect the chromosomes of the baby, but instead reflect chromosomal changes to the placenta or in the mother (Chromosomal mosaicism)

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9.) How will I receive my results of the Serenity NIPT?

Your results will be sent to you in a report to the email address that you provide us with. If any of your results come back as “Aneuploidy detected” we will provide you with an appointment with our Healthcare Professionals who will explain everything to you, a report of the results will also be sent to your own healthcare provider.

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10.) When will I get the results of my Serenity NIPT?

Once the blood reaches the lab the turnaround time is 7 working days, we aim to have the results to you in 10 working days from the day of your test.

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11.) What does a “No Aneuploidy detected” result mean?

Your results will tell whether or not trisomies 21, 18, 13 or sex chromosome abnormalities (if these were ordered) are highly suspected in this pregnancy. A No Aneuploidy Detected test result means that this test identified the expected number of copies of chromosomes reported.

Sex chromosomes will be reported as No Aneuploidy Detected, or Aneuploidy Detected. In the case of a twin pregnancy, the Y chromosome presence will be reported as Detected or Not Detected.

There is a 0.026% false negative rate with the Serenity test, this means that a “No aneuploidy detected” result you still have 0.026% chance of the foetus having a trisomy 21, 18, 13 , X or Y. You should only proceed with the test on the basis that you understand the false negative and false positive rate of the test.

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12.) What does “An Aneuploidy Detected” result mean?

Your results will tell whether or not trisomies 21, 18, 13 or sex chromosome abnormalities (if these were ordered) are highly suspected in this pregnancy.An Aneuploidy Detected test result means that this test identified too many or too few copies of one of the chromosomes as seen on the report. This can indicate either a trisomy or a sex chromosome aneuploidy.

Sex chromosomes will be reported as No Aneuploidy Detected, or Aneuploidy Detected. In the case of a twin pregnancy, the Y chromosome presence will be reported as Detected or Not Detected.

There is a 0.026% false negative rate with the Serenity test, this means that a “No aneuploidy detected” result you still have 0.026% chance of the foetus having a trisomy 21, 18, 13 , X or Y. You should only proceed with the test on the basis that you understand the false negative and false positive rate of the test.

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13.) Can I have the Serenity Test when I am expecting twins?

Yes, the Serenity Prenatal Test can be used in twin pregnancies, however is not suitable in cases of a vanishing twin or where there are more than 2 foetuses.

For Twin pregnancies the Sex chromosome analysis can only be carried out to test the foetal sex; Y chromosome (MALE) presence will be reported as Detected or Not Detected.

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14.) How many guests can I bring with me?

You can bring 2 guests along with you to have the Serenity prenatal test.

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15.) Do I need to bring anything with me?

Please ensure that you bring your antenatal records when you attend for your Serenity NIPT appointment so that we can contact your health professionals if necessary.

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16.) Do I need a full bladder for my scan?

If you are coming for the test between 10 and 12 weeks of pregnancy we recommend that you attend with a full bladder. This is because at this stage of pregnancy the uterus is small and full bladder pushes the uterus up and gives a clearer picture of the foetus.*
*Scar and adipose tissue can also make it more difficult to get a clear picture of the foetus, in these cases a full bladder is also advantageous.

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17.) How do I pay?

Payment for the Serenity prenatal test will be taken when you attend for the dating scan and can be made by cash, credit/debit card. Cheques are not accepted.

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18.) Should I still attend my Hospital appointments?

Yes. Serenity prenatal test should be regarded as an additional test and is not part of your routine antenatal care. It is important that you attend all your hospital appointments.

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19.) What are the limitations of the Serenity NIPT?

The Serenity NIPT is not intended or validated for diagnosis or detection of mosacism, partial trisomy or translocations. Certain rare biological conditions may also affect the accuracy of the test. Results for twin pregnancies reflect the probability that the pregnancy involves at least one affected foetus. For twin pregnancies male results apply to one or both foetuses.
Not all trisomy foetuses will be detected. Some trisomy foetuses may have “No aneuploidy detected” results. Some non-trisomy foetuses may have “A aneupolidy detected” results. False negative and false positive results are possible. A “No aneupolidy detected” result does not guarantee an unaffected pregnancy due to the screening limitations of the test. Serenity provides a risk assessment, not a diagnosis and results should be considered in the context of other clinical criteria. It is recommended that “an aneuploidy detected” result be confirmed through diagnostic test such as amniocentesis or CVS.

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20.) What if an abnormality is found?

If your results are returned as “An aneupolidy detected” we will arrange an appointment with our Healthcare Professionals who will explain the results to you and answer an questions that you may have. We will also write a report and send it to your healthcare professional. We would recommend that you also make an appointment with your healthcare professional to discuss you options of having a diagnostic test such as amniocentesis or CVS.

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